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Case definition for avian influenza - H5N1

a) Suspected case of avian influenza (H5N1)

  1. Clinical presentation
    • Fever ( › or = 38°C) OR history of fever AND respiratory symptoms (cough or shortness of breath) requiring hospitalization.

    OR
    • Death from unexplained respiratory illness
    AND
  2. Epidemiological criteria
    • History of travel in the 7 days prior to onset of symptoms to any affected area AND close contact (within 1 metre) with live or dead domestic fowl, wild birds, or swine in any setting, including bird markets.

    • OR one of the following
      • Close contact ( touching/speaking distance) with other case(s) of severe respiratory illness or unexplained death from above areas.
      • Part of a Health Care Worker cluster of severe unexplained respiratory illness.
      • A Laboratory worker with potential exposure to influenza A (H5N1)
      Fever ( 38°C) OR history of fever AND respiratory symptoms (cough or shortness of breath) requiring hospitalization.

b) Probable case of influenza A (H5N1)
Limited laboratory evidence of influenza A (H5N1).

c) Confirmed case definition for influenza H5N1
A confirmed case of influenza H5N1 infection is an individual for whom laboratory testing demonstrates one or more of the following:

  • Positive viral culture for influenza A/H5.
  • Positive polymerase chain reaction (PCR) for influenza A/H5.
  • Positive immunofluorescence antibody (IFA) test to H5 antigen using H5 monoclonal antibodies.
  • 4-fold rise in H5 specific antibody titre in paired serum samples.

The laboratory tests for the diagnosis of influenza A/H5 infection included in the case definition are considered the standard for the identification of these viruses.
 
 
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